Sometimes, malicious and other potentially unwanted software, including rootkits, try to install themselves on your PC. This can happen when you connect to the Internet or install some programs from a CD, DVD, or other media. Once on your PC, this software might run immediately, or it might run at unexpected times. Windows Defender Offline can help remove such hard to find malicious and potentially unwanted programs using definitions that recognize threats. Definitions are files that provide an encyclopedia of potential software threats. Because new threats appear daily, it's important to always have the most up-to-date definitions installed in Windows Defender Offline. Armed with definition files, Windows Defender Offline can detect malicious and potentially unwanted software, and then notify you of the risks.
For both the PC infected with a virus or malware, and the PC that you are creating the bootable media on, you'll need PCs with the following minimum requirements.
Operating system:
Windows XP Service Pack 3
Windows Vista, Windows Vista with SP1, Windows Vista with SP2, or higher
Windows 7, Windows 7 with SP1, or higher
Windows Developer Preview, Windows 8 Consumer Preview, Windows 8 Release Preview
2) Select the appropriate bootable medium. Once you start the creation, it will download the package and latest updates from Microsoft official site. So, make sure you have direct or proxy internet connection with download access.

3) If you select CD, then insert the blank CD in next screen, if it is an USB drive, just remember this program will format the USB drive and install System Sweeper.

ISO can be ideal to mount and use in working computer or any virtual machines.
4) Successful message will appear after the completion.
5) If it is a physical computer which can’t be booted or cleaned while OS is working, then insert the CD or USB and boot from it. Mount the ISO file to CD drive and boot the virtual machine for cleaning.
Press any key to boot from CD. It loads like latest Microsoft Operating Systems. Malware and virus clean up should start nicely.
source
Windows Defender Offline system requirements
For both the PC infected with a virus or malware, and the PC that you are creating the bootable media on, you'll need PCs with the following minimum requirements.
Operating system:
Windows XP Service Pack 3
Windows Vista, Windows Vista with SP1, Windows Vista with SP2, or higher
Windows 7, Windows 7 with SP1, or higher
Windows Developer Preview, Windows 8 Consumer Preview, Windows 8 Release Preview
How to Create A System Sweeper Bootable CD,USB or ISO for a PC
1) Download the EXE file here.2) Select the appropriate bootable medium. Once you start the creation, it will download the package and latest updates from Microsoft official site. So, make sure you have direct or proxy internet connection with download access.

3) If you select CD, then insert the blank CD in next screen, if it is an USB drive, just remember this program will format the USB drive and install System Sweeper.

ISO can be ideal to mount and use in working computer or any virtual machines.
4) Successful message will appear after the completion.
5) If it is a physical computer which can’t be booted or cleaned while OS is working, then insert the CD or USB and boot from it. Mount the ISO file to CD drive and boot the virtual machine for cleaning.
Press any key to boot from CD. It loads like latest Microsoft Operating Systems. Malware and virus clean up should start nicely.
source
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